Python Tools for Visual Studio (PTVS) 1.1 Alpha! released to CodePlex is a free, open source plug-in for Visual Studio 2010 from Microsoft's Developer Division.
"PTVS turns Visual Studio into an IDE for Python, and enables developers to use all the major productivity features of Visual Studio to build Python code using either CPython or IronPython and adds new features such as using High Performance Computing clusters to scale your code."
Together with one of the standard distros, you can turn Visual Studio into a powerful Technical Computing IDE.
In the video below, PTVS architect Sean Mortazavi and lead developer Dino Viehland demos the features released:
You can download Python Tools for Visual Studio 1.1 Alpha here.