Microsoft BizTalk Server 2006 R2 Service Pack 1 (SP1) is an update for BizTalk Server 2006 R2. The SP1 installation program that’s available on this page offers a unified installation experience: It will automatically detect and update all of the BizTalk Server components that are currently installed on your machine. It will also detect all BizTalk Server hotfixes currently installed, and will distinguish between hotfixes that predate this service pack, and those which were issued after this service pack was released. An SP1 Guide document is also available for download on this page, and describes the installation experience in detail. SP1 includes a roll-up of hotfixes from the BizTalk Server 2006 and 2006 R2 releases, some hotfixes from the BizTalk Server 2009 release, as well as some additional enhancements.
Download: BizTalk Server 2006 R2 Service Pack 1