When you use Refresh Server option to refresh a Publishing Server from Microsoft App-V Client MMC snap-in, you may receive error: "The Application Virtualization Client couldn't update publishing information from the server ServerName. No connection could be made because the target machine actively refused it. Error code: xxxxxxx-xxxxxx2A-0000274D."
This issue can occur if the App-V client cann't communicate with Publishing Server. For how to troubleshoot and resolve this issue see the following Knowledge Base article:
More Info: KB2266481