Below is a link to a short white paper which describes how MPSD deployed Service Manager to manage their 5,000 servers using incident and change management. MPSD is the operations team at Microsoft that runs Microsoft.com, MSDN, TechNet, and other large online properties you all use every day (including this blog! ).
Here's a 15 minute video/demo about MPSD's deployment of Service Manager:
More Info: White Paper