TwitZap is a web service that lets set up Twitter channels of stuff that matters to you, and updates your twitter stream in real-time; you don't have to refresh anything and talking to other TwitZap users is instant, even when Twitter is not. TwitZap helps you keep track of how many unread messages you have in each channel. You can also see and exchange instant tweets with other online TwitZap users.
More info: TwitZap
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