The latest version of PenOffice handwriting recognition software for Microsoft Windows-based computers and Tablet PCs, now supports all editions of Windows XP, Windows Vista, Microsoft Office XP or later, OpenOffice.org 3.0 and can be used with any pointing input device, such as graphic tablet, interactive while board, touch screen monitor, Tablet PC, online digital pen, and even standard computer mouse.

PenOffice also incorporates features that allow users to add handwritten notes to Microsoft Word, Excel and PowerPoint documents, embed control gestures into writing, create handwritten notes, utilize fill-screen drawings, and much more. 

More info: PenOffice