Moderator is a desktop application and a WordPress Plugin, built using Adobe AIR, that allows you to view and moderate comments from your desktop. Some of the features of this early release of the application include:

• Viewing unmoderated comments.
• Dock and system tray notifications of the number of unmoderated comments.
• Accept, delete, and spam comments from within the desktop client.
• Close application window, or minimize it to the system tray while running.
• Shows the Gravatar icons for the user who posted the comment.

More info....