Of the back of the RTM that was released last night, Microsoft has also released a new  set of excellent documentation for App-V 4.5 RTM;

http://technet.microsoft.com/en-us/library/cc843848.aspx

The core areas that we look to cover in the new documentation are;

Technical Documentation

The technical documentation for Application Virtualization 4.5 in the TechNet Library contains the following sections:

• Microsoft Application Virtualization Management System Release Notes
• Planning and Deployment Guide for the Application Virtualization System
• Operations Guide for the Application Virtualization System
• Online Help for Application Virtualization
• Application Virtualization Glossary

This is a worthwhile bedtime read that will help you with your detailed design consideration and general best practice guidance.

Have a read before you go wild and deploy! This will save you potential pain in the future and its great to have these documents on the actual release of the product!