On the Microsoft TechNet forums, a handful of users began reporting (in early April) that after installing Vista SP1 various applications would stop launching and instead gave the error "Not a valid Win32 application." Users found that Excel would often spit this message out and if they tried running it under administrative rights, the error would change to "Insufficient system resources exist to complete the requested service."
Most often it would be Microsoft Office applications crashing, but reinstalling the suite did not fix the problem. The issue, which does not occur every time the application is launched, happens to a select number of users regardless of whether SP1 was rolled out on a fresh install of Windows Vista or not.
Microsoft, Windows Vista, SP1, Vista SP1, Application Crash, Win32