Symptoms: After installing McAfee VirusScan Enterprise 8.5i some SoftGrid client actions seems to be blocked. For example, if you try to start Microsoft Word 2003 /2007 or another Office Application via SoftGrid you may get the following error:

"The operation system is not presently configured to run this application."

Furthermore you may see some Event log entries like:

Event Type: Error
Event Source: SideBySide
Event Category: None
Event ID: 59
Description: Generate Activation Context failed for C:\Program Files\Common Files\Microsoft Shared\OFFICE11\MSO.DLL. Reference error message: The operation completed successfully.

Event Type: Error
Event Source: SideBySide
Event Category: None
Event ID: 59
Description: Resolve Partial Assembly failed for Microsoft.Windows.Common-Controls. Reference error message: The system cannot find the path specified.

Event Type: Error
Event Source: SideBySide
Event Category: None
Event ID: 59
Description: Generate Activation Context failed for C:\PROGRA~1\COMMON~1\MICROS~1\OFFICE11\mso.dll. Reference error message: The operation completed successfully.

Event Type: Error
Event Source: SideBySide
Event Category: None
Event ID: 59
Description: Resolve Partial Assembly failed for Microsoft.Windows.Common-Controls. Reference error message: The system cannot find the path specified

Cause: Due to the BOP feature (Buffer Overflow Protection) in McAfee VirusScan, SoftGrid may be prevented from hooking the DLL call to point Office Applications to the Q Drive.

Resolution: There are three possible solutions:

1. Create an empty directory for the application on the affected system(s).
   Launch Windows Explorer.
   Navigate to C:\program files\Common Files\Microsoft Shared\

   Create an empty instance of the virtual directory containing the Microsoft Office applications.

   Example: c:\program files\Common Files\Microsoft Shared\Office 11 for Office 2003 or \Office12 for Office 2007

2. Install VirusScan Enterprise (VSE) 8.5i without Buffer Overflow Protection (BOP) enabled.
3. Add the name of the Microsoft Office application to the list of excluded processes in the Buffer Overflow Protection feature.
   Example: winword.exe

   NOTE: McAfee does not recommend excluding executables unless there is no other option and you are aware of the potential risks.

   Note: Microsoft recommends the first workaround above.

Source:→ Microsoft

SoftGrid, Microsoft Application Virtualization, AppVirt, McAfee, VirusScan, Applications, Torubleshooting